How are peptides different from hormones?

Hormones like testosterone operate through feedback loops — inject exogenous testosterone and your body suppresses natural production. Peptides work differently: they amplify the signal your body is already sending without shutting it down. This is a significant part of why peptide protocols are generally considered lower-risk than hormone replacement, and why stopping is typically smoother.

Do I need a doctor for a peptide stack?

For GLP-1 medications, yes — they require a prescription from a licensed provider. For GH peptides like Ipamorelin, access is through compounding pharmacies and peptide clinics, ideally with physician oversight. The more compounds you run simultaneously, the more valuable a physician who knows this space becomes.

What does the Recomp Stack cost per month?

The GLP-1 component runs $150–$350/month through online programs. Adding Ipamorelin/CJC-1295 through a peptide clinic typically adds $150–$250/month. Total: $300–$600/month depending on provider and dose.

Is the muscle-sparing claim on retatrutide real?

Not quite. A Lancet Diabetes & Endocrinology sub-study found that approximately 37–40% of total weight lost on retatrutide was lean mass — comparable to other GLP-1s (which typically run 25–39%). The weight loss numbers are genuinely impressive (~24% at 48 weeks in Phase II), but the "get shredded without losing muscle" narrative circulating in fitness communities isn't supported by the published data.

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Last updated April 2026 · How we research

Peptide stacks

Most people start with a GLP-1 and stop there. That's usually the right call. But if your goal is body recomposition — losing fat while keeping muscle — one additional compound makes a meaningful difference. Here's what that looks like.

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The Starter Stack

Weight loss

Compounds

Semaglutide or TirzepatideAppetite suppression, primary fat loss driverRx via telehealth

One compound. Most people don't need anything else. Semaglutide or tirzepatide alone produces meaningful, sustained weight loss for the majority of people who use it consistently. Run this for at least 3–6 months before adding complexity — the results will tell you whether you need more.

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The Recomp Stack

Weight loss + muscle retention

Compounds

Semaglutide or TirzepatidePrimary fat loss and appetite controlRx via telehealth

Ipamorelin / CJC-1295Growth hormone pulse — signals the body to preserve lean massPeptide clinic or compounding pharmacy

GLP-1 medications suppress appetite aggressively. In the absence of a muscle-preservation signal, the body loses lean mass alongside fat — roughly 25–40% of total weight lost is muscle with GLP-1s alone. A growth hormone secretagogue like Ipamorelin/CJC-1295 provides that signal. More relevant at higher doses, or for anyone 35+ who is already active and wants to protect what they've built.

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The GLP-1 is the foundation

Every stack starts here. Compare the top online programs before adding anything else.

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Get the 2026 GLP-1 Cost & Eligibility Cheat Sheet

One page: real monthly costs for compounded vs brand semaglutide and tirzepatide, the BMI thresholds that qualify you, and the five questions to ask before you pay. We'll email it now.

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Frequently Asked Questions

Related: Semaglutide vs tirzepatide

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Medical Disclaimer: This page is for informational purposes only and does not constitute medical advice. Peptides and GLP-1 medications require a prescription and should only be taken under the supervision of a licensed healthcare provider. Individual results vary. Always consult a doctor before starting any new medication or compound.